Neural Engineering Research Laboratory University of Campinas

Publications

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2026

A Biomechanical Hand Model to Quantify Finger Joint Kinematics Using a 3D Motion Capture System
A Biomechanical Hand Model to Quantify Finger Joint Kinematics Using a 3D Motion Capture System
Valeria Avilés-Carrillo, Ricardo G. Molinari, Guilherme A. G. De Villa, Leonardo A. Elias
openRxiv  ·  11 Feb 2026  ·  doi:10.64898/2026.02.09.704796
MyoGen: Unified Biophysical Modeling of Human Neuromotor Activity and Resulting Signals
MyoGen: Unified Biophysical Modeling of Human Neuromotor Activity and Resulting Signals
Raul C. Sîmpetru, Ricardo G. Molinari, Devon R. Rohlf, Rebeka L. Batichotti, Renato N. Watanabe, Leonardo A. Elias, Alessandro Del Vecchio
openRxiv  ·  02 Jan 2026  ·  doi:10.64898/2026.01.01.697284
Da Neurofisiologia à Neuroengenharia: Investigações Experimentais e Computacionais sobre o Sistema Sensório-Motor Humano
Da Neurofisiologia à Neuroengenharia: Investigações Experimentais e Computacionais sobre o Sistema Sensório-Motor Humano
Leonardo Abdala Elias
figshare  ·  01 Jan 2026  ·  doi:10.6084/m9.figshare.30976438
A Wearable Platform for Real-Time Control of a Prosthetic Hand by High-Density EMG
A Wearable Platform for Real-Time Control of a Prosthetic Hand by High-Density EMG
Ricardo G. Molinari, Valeria Avilés-Carrillo, Guilherme A. G. De Villa, Leonardo A. Elias
IEEE Access  ·  01 Jan 2026  ·  doi:10.1109/ACCESS.2026.3670500
HD sEMG of Forearm Muscles and 3D Hand Kinematics During Sinusoidally-Modulated Finger Movements and Grasping Tasks
HD sEMG of Forearm Muscles and 3D Hand Kinematics During Sinusoidally-Modulated Finger Movements and Grasping Tasks
Valeria Avilés Carrillo, Ricardo Gonçalves Molinari, Guilherme Augusto Gomes De Villa, Leonardo Abdala Elias
figshare  ·  01 Jan 2026  ·  doi:10.6084/m9.figshare.31032934

2025

Markov chain-based computational model to assess user skills in sequential motor imagery tasks
Markov chain-based computational model to assess user skills in sequential motor imagery tasks
Cristian David Guerrero-Mendez, Hamilton Rivera-Flor, Denis Delisle-Rodriguez, Leonardo Abdala Elias, Teodiano Freire Bastos-Filho
Computers in Biology and Medicine  ·  01 Oct 2025  ·  doi:10.1016/j.compbiomed.2025.111048
Reassessment of isometric muscle force complexity under different contraction intensities, joint angles, and visual feedback conditions
Reassessment of isometric muscle force complexity under different contraction intensities, joint angles, and visual feedback conditions
Ellen Pereira Zambalde, Carina Marconi Germer, Ricardo Gonçalves Molinari, Francesco Negro, Jakob Dideriksen, Leonardo Abdala Elias
European Journal of Applied Physiology  ·  01 Jul 2025  ·  doi:10.1007/s00421-025-05880-5
Design and usability assessment of touchscreen interface in medical devices: a case study of a neonatal incubator
Design and usability assessment of touchscreen interface in medical devices: a case study of a neonatal incubator
Carlos Alessandro Bassi Viviani, Leonardo Abdala Elias, Saide Jorge Calil
Research on Biomedical Engineering  ·  05 Feb 2025  ·  doi:10.1007/s42600-025-00401-x
Visual Gain and Feedback Significantly Influence Alpha-Band Corticomuscular Coherence in Plantar Flexion Isometric Force Task
Visual Gain and Feedback Significantly Influence Alpha-Band Corticomuscular Coherence in Plantar Flexion Isometric Force Task
Cristian D. Guerrero-Mendez, Felipe C. Pinheiro, Diana R. de Toledo, Felipe F. de Lima, André F. Kohn, Leonardo A. Elias
Biosystems & Biorobotics  ·  01 Jan 2025  ·  doi:10.1007/978-3-031-77588-8_161

2024

Shoulder Kinematics Predicts Lateral Asymmetries in Functional Tests of Hand Dexterity
Shoulder Kinematics Predicts Lateral Asymmetries in Functional Tests of Hand Dexterity
Guilherme Augusto Gomes De Villa, Ricardo G. Molinari, Valeria A. Carrillo, Leonardo Abdala Elias
Biosystems & Biorobotics  ·  01 Jan 2024  ·  doi:10.1007/978-3-031-77584-0_2
Modulation of Myoelectric Activity by a Virtual Interface of a Prosthetic Hand
Modulation of Myoelectric Activity by a Virtual Interface of a Prosthetic Hand
Valeria A. Carrillo, Ricardo G. Molinari, Guilherme A. G. De Villa, Leonardo A. Elias
Biosystems & Biorobotics  ·  01 Jan 2024  ·  doi:10.1007/978-3-031-77584-0_113
Factors Affecting the Performance of FastICA Algorithm for Decomposition of High-Density Surface Electromyogram
Factors Affecting the Performance of FastICA Algorithm for Decomposition of High-Density Surface Electromyogram
Mateus Augusto Schneider Castilhos, Leonardo Abdala Elias
IFMBE Proceedings  ·  01 Jan 2024  ·  doi:10.1007/978-3-031-49404-8_43
Estimation of the Neural Drive to Forearm Muscles in Periodic Movements of Fingers
Estimation of the Neural Drive to Forearm Muscles in Periodic Movements of Fingers
Ricardo G. Molinari, Valeria A. Carrillo, Guilherme A. G. De Villa, Leonardo A. Elias
Biosystems & Biorobotics  ·  01 Jan 2024  ·  doi:10.1007/978-3-031-77584-0_110
Assessment of Neuromuscular Function in Patients with Long-Term Symptoms of COVID-19
Assessment of Neuromuscular Function in Patients with Long-Term Symptoms of COVID-19
Emilia F. Cremasco, Ellen P. Zambalde, Carina M. Germer, Leonardo A. Elias
IFMBE Proceedings  ·  01 Jan 2024  ·  doi:10.1007/978-3-031-49407-9_20

2023

Simulating The Effects of Low Intensity Focused Ultrasound in Parkinson s Disease
Simulating The Effects of Low Intensity Focused Ultrasound in Parkinson's Disease
Ítalo Karmann Aventurato, Marcelo Ramos Romano, Leonardo Abdala Elias
2023 11th International IEEE/EMBS Conference on Neural Engineering (NER)  ·  24 Apr 2023  ·  doi:10.1109/NER52421.2023.10123760
Editorial: Towards an understanding of spinal and corticospinal pathways and mechanisms
Editorial: Towards an understanding of spinal and corticospinal pathways and mechanisms
Leonardo Abdala Elias, Pilwon Hur, Gary C. Sieck
Frontiers in Human Neuroscience  ·  21 Mar 2023  ·  doi:10.3389/FNHUM.2023.1181647

2022

Effects of voluntary contraction on the soleus H-reflex of different amplitudes in healthy young adults and in the elderly
Effects of voluntary contraction on the soleus H-reflex of different amplitudes in healthy young adults and in the elderly
Leandra Batista-Ferreira, Natielle Ferreira Rabelo, Gabriel Menezes da Cruz, Juliana Nunes de Almeida Costa, Leonardo Abdala Elias, Rinaldo André Mezzarane
Frontiers in Human Neuroscience  ·  15 Dec 2022  ·  doi:10.3389/FNHUM.2022.1039242
Effects of light finger touch on the regularity of center-of-pressure fluctuations during quiet bipedal and single-leg postural tasks
Effects of light finger touch on the regularity of center-of-pressure fluctuations during quiet bipedal and single-leg postural tasks
Jéssica Rodrigues Lara, Cristiano Rocha da Silva, Felipe Fava de Lima, Marcos Camargo da Silva, André Fabio Kohn, Leonardo Abdala Elias, Fernando Henrique Magalhães
Gait & Posture  ·  01 Jul 2022  ·  doi:10.1016/J.GAITPOST.2022.05.036
Influence of central and peripheral motor unit properties on isometric muscle force entropy: A computer simulation study
Influence of central and peripheral motor unit properties on isometric muscle force entropy: A computer simulation study
Jakob Dideriksen, Leonardo Abdala Elias, Ellen Pereira Zambalde, Carina Marconi Germer, Ricardo Gonçalves Molinari, Francesco Negro
Journal of Biomechanics  ·  01 Jun 2022  ·  doi:10.1016/J.JBIOMECH.2021.110866
High-Resolution Magic-Angle Spinning NMR Spectroscopy for Evaluation of Cell Shielding by Virucidal Composites Based on Biogenic Silver Nanoparticles, Flexible Cellulose Nanofibers and Graphene Oxide
High-Resolution Magic-Angle Spinning NMR Spectroscopy for Evaluation of Cell Shielding by Virucidal Composites Based on Biogenic Silver Nanoparticles, Flexible Cellulose Nanofibers and Graphene Oxide
Danijela Stanisic, Guilherme C. F. Cruz, Leonardo Abdala Elias, Junko Tsukamoto, Clarice W. Arns, Douglas Soares da Silva, Stanislav Mochkalev, Raluca Savu, Ljubica Tasic
Frontiers in Bioengineering and Biotechnology  ·  12 May 2022  ·  doi:10.3389/FBIOE.2022.858156
A Case Study on the Removal of Blinking Artifact in Electroencephalogram Signals via Stochastic Filtering
A Case Study on the Removal of Blinking Artifact in Electroencephalogram Signals via Stochastic Filtering
Rebecca Fernandes Ribeiro, Victor Baptista Frencl, Leonardo Abdala Elias, João Bosco Ribeiro do Val
Journal of Control, Automation and Electrical Systems  ·  12 Jan 2022  ·  doi:10.1007/S40313-021-00890-Y
Influence of Visual Feedback Removal on the Neural Control Strategies During Isometric Force Production
Influence of Visual Feedback Removal on the Neural Control Strategies During Isometric Force Production
C. M. Germer, E. P. Zambalde, L. A. Elias
IFMBE Proceedings  ·  01 Jan 2022  ·  doi:10.1007/978-3-030-70601-2_319

2021

Entropy of motor unit activity and surface electromyogram in an isometric force task
Entropy of motor unit activity and surface electromyogram in an isometric force task
Ellen P. Zambalde, Carina M. Germer, Leonardo A. Elias
17th International Symposium on Medical Information Processing and Analysis  ·  10 Dec 2021  ·  doi:10.1117/12.2606261
Surface EMG cross talk quantified at the motor unit population level for muscles of the hand, thigh, and calf
Surface EMG cross talk quantified at the motor unit population level for muscles of the hand, thigh, and calf
Carina M. Germer, Dario Farina, Leonardo A. Elias, Stefano Nuccio, François Hug, Alessandro Del Vecchio
Journal of Applied Physiology  ·  01 Aug 2021  ·  doi:10.1152/JAPPLPHYSIOL.01041.2020
A Data-Driven Biophysical Computational Model of Parkinson s Disease Based on Marmoset Monkeys
A Data-Driven Biophysical Computational Model of Parkinson’s Disease Based on Marmoset Monkeys
Caetano M. Ranieri, Jhielson M. Pimentel, Marcelo R. Romano, Leonardo A. Elias, Roseli A. F. Romero, Michael A. Lones, Mariana F. P. Araujo, Patricia A. Vargas, Renan C. Moioli
IEEE Access  ·  01 Jan 2021  ·  doi:10.1109/ACCESS.2021.3108682

2020

Open collaborative writing with Manubot
Open collaborative writing with Manubot
Daniel S. Himmelstein, Vincent Rubinetti, David R. Slochower, Dongbo Hu, Venkat S. Malladi, Casey S. Greene, Anthony Gitter
PLOS Computational Biology  ·  04 Dec 2020  ·  doi:10.1371/journal.pcbi.1007128
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Assessment of force control improvement induced by sinusoidal vibrotactile stimulation in dominant and non-dominant hands
Assessment of force control improvement induced by sinusoidal vibrotactile stimulation in dominant and non-dominant hands
Carina Marconi Germer, Luciana Sobral Moreira, Leonardo Abdala Elias
Research on Biomedical Engineering  ·  10 Nov 2020  ·  doi:10.1007/s42600-020-00111-6
Evaluation of Frequency-Dependent Effects of Deep Brain Stimulation in a Cortex-Basal Ganglia-Thalamus Network Model of Parkinson s Disease
Evaluation of Frequency-Dependent Effects of Deep Brain Stimulation in a Cortex-Basal Ganglia-Thalamus Network Model of Parkinson’s Disease
Marcelo R. Romano, Renan C. Moioli, Leonardo A. Elias
2020 42nd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)  ·  01 Jul 2020  ·  doi:10.1109/EMBC44109.2020.9176570
Reliable measurement of incisal bite force for understanding the control of masticatory muscles
Reliable measurement of incisal bite force for understanding the control of masticatory muscles
Luciana S. Moreira, Leonardo A. Elias, Carina M. Germer, Evanisi T. Palomari
Archives of Oral Biology  ·  01 Apr 2020  ·  doi:10.1016/J.ARCHORALBIO.2020.104683
Neurophysiological correlates of force control improvement induced by sinusoidal vibrotactile stimulation
Neurophysiological correlates of force control improvement induced by sinusoidal vibrotactile stimulation
Carina Marconi Germer, Alessandro Del Vecchio, Francesco Negro, Dario Farina, Leonardo Abdala Elias
Journal of Neural Engineering  ·  31 Jan 2020  ·  doi:10.1088/1741-2552/AB5E08
Constructing knowledge graphs and their biomedical applications
Constructing knowledge graphs and their biomedical applications
David N. Nicholson, Casey S. Greene
Computational and Structural Biotechnology Journal  ·  01 Jan 2020  ·  doi:10.1016/j.csbj.2020.05.017

2019

The human central nervous system transmits common synaptic inputs to distinct motor neuron pools during non synergistic digit actions
The human central nervous system transmits common synaptic inputs to distinct motor neuron pools during non‐synergistic digit actions
A. Del Vecchio, C. M. Germer, L. A. Elias, Q. Fu, J. Fine, M. Santello, D. Farina
The Journal of Physiology  ·  30 Oct 2019  ·  doi:10.1113/JP278623
A computer simulation study on the influences of loss and damage of primary muscle spindle afferents on soleus muscle stretch reflex
A computer simulation study on the influences of loss and damage of primary muscle spindle afferents on soleus muscle stretch reflex
Eliane C. Rodrigues, Leonardo A. Elias
2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)  ·  01 Jul 2019  ·  doi:10.1109/EMBC.2019.8857466
Sinusoidal vibrotactile stimulation differentially improves force steadiness depending on contraction intensity
Sinusoidal vibrotactile stimulation differentially improves force steadiness depending on contraction intensity
Carina Marconi Germer, Luciana Sobral Moreira, Leonardo Abdala Elias
Medical & Biological Engineering & Computing  ·  14 Jun 2019  ·  doi:10.1007/S11517-019-01999-8

2018

Perspectives on the modeling of the neuromusculoskeletal system to investigate the influence of neurodegenerative diseases on sensorimotor control
Perspectives on the modeling of the neuromusculoskeletal system to investigate the influence of neurodegenerative diseases on sensorimotor control
Leonardo Abdala Elias, Débora Elisa da Costa Matoso, Renato Naville Watanabe, André Fabio Kohn
Research on Biomedical Engineering  ·  17 May 2018  ·  doi:10.1590/2446-4740.00118
Sci-Hub provides access to nearly all scholarly literature
Sci-Hub provides access to nearly all scholarly literature
Daniel S Himmelstein, Ariel Rodriguez Romero, Jacob G Levernier, Thomas Anthony Munro, Stephen Reid McLaughlin, Bastian Greshake Tzovaras, Casey S Greene
eLife  ·  01 Mar 2018  ·  doi:10.7554/eLife.32822

2017

Reassessment of Non-Monosynaptic Excitation from the Motor Cortex to Motoneurons in Single Motor Units of the Human Biceps Brachii
Reassessment of Non-Monosynaptic Excitation from the Motor Cortex to Motoneurons in Single Motor Units of the Human Biceps Brachii
Tsuyoshi Nakajima, Toshiki Tazoe, Masanori Sakamoto, Takashi Endoh, Satoshi Shibuya, Leonardo A. Elias, Rinaldo A. Mezzarane, Tomoyoshi Komiyama, Yukari Ohki
Frontiers in Human Neuroscience  ·  30 Jan 2017  ·  doi:10.3389/FNHUM.2017.00019
A longitudinal assessment of myoelectric activity, postural sway, and low-back pain during pregnancy
A longitudinal assessment of myoelectric activity, postural sway, and low-back pain during pregnancy
Luciana S. Moreira, Leonardo A. Elias, Adriane B. Gomide, Marcus F. Vieira, Waldemar N. D. Amaral
Acta of Bioengineering and Biomechanics; 03/2017; ISSN 1509-409X  ·  01 Jan 2017  ·  doi:10.5277/ABB-00753-2016-02

2015

D1 and D2 Inhibitions of the Soleus H-Reflex Are Differentially Modulated during Plantarflexion Force and Position Tasks
D1 and D2 Inhibitions of the Soleus H-Reflex Are Differentially Modulated during Plantarflexion Force and Position Tasks
Fernando Henrique Magalhães, Leonardo Abdala Elias, Cristiano Rocha da Silva, Felipe Fava de Lima, Diana Rezende de Toledo, André Fabio Kohn
PLOS ONE  ·  24 Nov 2015  ·  doi:10.1371/JOURNAL.PONE.0143862
Enhanced D1 and D2 Inhibitions Induced by Low-Frequency Trains of Conditioning Stimuli: Differential Effects on H- and T-Reflexes and Possible Mechanisms
Enhanced D1 and D2 Inhibitions Induced by Low-Frequency Trains of Conditioning Stimuli: Differential Effects on H- and T-Reflexes and Possible Mechanisms
Rinaldo André Mezzarane, Fernando Henrique Magalhães, Vitor Martins Chaud, Leonardo Abdala Elias, André Fabio Kohn
PLOS ONE  ·  25 Mar 2015  ·  doi:10.1371/JOURNAL.PONE.0121496

2014

Spinal Mechanisms May Provide a Combination of Intermittent and Continuous Control of Human Posture: Predictions from a Biologically Based Neuromusculoskeletal Model
Spinal Mechanisms May Provide a Combination of Intermittent and Continuous Control of Human Posture: Predictions from a Biologically Based Neuromusculoskeletal Model
Leonardo Abdala Elias, Renato Naville Watanabe, André Fabio Kohn
PLoS Computational Biology  ·  13 Nov 2014  ·  doi:10.1371/JOURNAL.PCBI.1003944

2013

Influences of premotoneuronal command statistics on the scaling of motor output variability during isometric plantar flexion
Influences of premotoneuronal command statistics on the scaling of motor output variability during isometric plantar flexion
Renato N. Watanabe, Fernando H. Magalhães, Leonardo A. Elias, Vitor M. Chaud, Emanuele M. Mello, André F. Kohn
Journal of Neurophysiology  ·  01 Dec 2013  ·  doi:10.1152/JN.00073.2013
Low-frequency fluctuations of plantar flexion torque in force and position control tasks studied experimentally and by a neuromusculoskeletal model
Low-frequency fluctuations of plantar flexion torque in force and position control tasks studied experimentally and by a neuromusculoskeletal model
Renato N. Watanabe, Leonardo A. Elias, Andre F. Kohn
2013 6th International IEEE/EMBS Conference on Neural Engineering (NER)  ·  01 Nov 2013  ·  doi:10.1109/NER.2013.6696054
Web-based neuromuscular simulator applied to the teaching of principles of neuroscience
Web-based neuromuscular simulator applied to the teaching of principles of neuroscience
Leonardo Abdala Elias, André Fabio Kohn
Revista Brasileira de Engenharia Biomédica  ·  01 Jan 2013  ·  doi:10.4322/rbeb.2013.026
Individual and collective properties of computationally efficient motoneuron models of types S and F with active dendrites
Individual and collective properties of computationally efficient motoneuron models of types S and F with active dendrites
Leonardo Abdala Elias, André Fabio Kohn
Neurocomputing  ·  01 Jan 2013  ·  doi:10.1016/J.NEUCOM.2012.06.038

2012

A simulation study of the effects of activation-dependent muscle stiffness on proprioceptive feedback and short-latency reflex
A simulation study of the effects of activation-dependent muscle stiffness on proprioceptive feedback and short-latency reflex
Vitor M. Chaud, Leonardo A. Elias, Renato N. Watanabe, Andre F. Kohn
2012 4th IEEE RAS & EMBS International Conference on Biomedical Robotics and Biomechatronics (BioRob)  ·  01 Jun 2012  ·  doi:10.1109/BioRob.2012.6290871
Models of passive and active dendrite motoneuron pools and their differences in muscle force control
Models of passive and active dendrite motoneuron pools and their differences in muscle force control
Leonardo Abdala Elias, Vitor Martins Chaud, André Fabio Kohn
Journal of Computational Neuroscience  ·  06 May 2012  ·  doi:10.1007/S10827-012-0398-4

2009

Accommodation in motoneuron models with passive dendrite: Response to linearly rising currents
Accommodation in motoneuron models with passive dendrite: Response to linearly rising currents
Marcus Fraga Vieira, Leonardo Abdala Elias
Neurocomputing  ·  01 Aug 2009  ·  doi:10.1016/J.NEUCOM.2009.02.006